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Interestingly, pre-treatment of cells with N-acetylcysteine, a precursor of glutathione, and a thiol antioxidant failed to block the depletion of glutathione, generation of ROS, and activation of caspase-3

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The inclusion criteria were (1) research/review articles on sources and generation of reactive free radicals, (2) research/review articles with experimental data on ROS-associated diseases, (3) research/review articles with experimental data on antioxidant activity, (4) research/review articles exploring the mode of action of synthetic as well as natural antioxidants

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