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Single daily dosing suits general recovery and maintenance while split dosing at 0.25 mg every 12 hours maintains more consistent tissue levels beneficial for acute injuries

Hostynek and colleagues quantified percutaneous absorption of the intact GHK-Cu complex through human skin in 2010, supporting bioavailability of the chelate as a unit rather than as separated peptide and copper

While BPC-157 itself demonstrates gastric stability, the enteric coating provides an additional layer of protection and ensures consistent release in the intestinal lumen, where the majority of peptide absorption occurs

doi: 10.3389/fphar.2024.1330797 Received 31 October 2023 Accepted 19 January 2024 Published 01 February 2024 Volume 15 - 2024 Edited by Sirajudheen Anwar, University of Hail, Saudi Arabia Reviewed by Talib Hussain, University of Hail, Saudi Arabia Rohit Kumar Tiwari, Sharda University, India Updates Copyright 2024 Buczyska, Sidorkiewicz, Krtowski and Adamska