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The proportion of participants with prediabetes was 40.6% in SURMOUNT 1 34 while it was not reported in SURMOUNT 3 35 and 4 36 , enrolling patients with a mean HbA1c of 5.5%

In yet other embodiments, the formulation or composition provides an immediate release and extended release formulation or composition of at least one otic agent, and at least one therapeutic agent

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DEER was for instance used to characterize tau amyloid aggregates made of recombinant protein and showed that they adopt heterogeneous structures that are drastically different from brain-derived structures (Fichou et al., 2018b)