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A 2002 retrospective case and control study published in the Annals of Hematology has found that vitamin B12 and folate deficiency can increase the risk of thrombosis ( 17 )

The action of nonsteroidal anti-inflammatory drugs in the digestive tract can also cause, among others, enteropathy, perforations, strictures, or lead to exacerbation or recurrence of digestive system diseases

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In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision