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In our review, the most investigated contrast in blood was old versus young adults (10/16), with a decrease in GSH levels reported in older adults by the majority of studies (6/9

Peripheral blood was obtained from patients who providedwritten informed consent as part of a protocol approved by theInstitutional Review Board of The University of Texas MDAnderson Cancer Center and in accordance with the Declarationof Helsinki

[19] [21] The compounds targeted in this manner by GSTs encompass a diverse range of environmental or otherwise exogenous toxins, including chemotherapeutic agents and other drugs, pesticides, herbicides, carcinogens, and variably-derived epoxides

Some randomized trials and pooled analyses report modest reductions in body mass index (BMI), triglycerides, total cholesterol, LDL cholesterol, and blood pressure with inositol supplementation.32 33 34 However, these outcomes are difficult to interpret in isolation