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The same reduction in adipogenic potential including a reduced capacity to produce leptin by cells in culture was found for adipose tissue removed by tumescent liposuction from women with lipedema compared to women without lipedema (67)

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Native rhIGF-1 in IGF-1 Deficiency Chernausek et al., Journal of Clinical Endocrinology & Metabolism (2007) Chernausek and colleagues conducted the pivotal long-term clinical trial of recombinant human IGF-1 (mecasermin) in pediatric patients with severe primary IGF-1 deficiency the trial that supported FDA approval of Increlex for this rare growth-failure population