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The new hypothesis proposes that a transient increase of intracellular diacylglycerol (DAG) activates theta isoform of protein kinase C (PKC) that causes increased serine phosphorylation of IRS-1/2 and consecutively decrease PI3K activation and glucose-transport activity leading to decrease intracellular glucose concentrations

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Within the thyroid, three iodothyronine deiodinases (DIO1, DIO2, and DIO3) depend on selenium for their enzymatic activity (127)

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