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Sorias laboratory, originally generated by Vogelstein laboratory

Tretinoin, aka retinoic acid, is the active ingredient our skin cells can understand and retinyl palmitate (RP) has to be converted by our metabolic machinery to actually do something

Reducing sodium intake helps

Abbreviations RA: Rheumatoid arthritis mTOR: Mechanistic target of rapamycin raptor: Regulatory-associated protein of TOR mlst8: Mammalian lethal with sec-13 protein 8 deptor: DEP domaincontaining mTOR interacting protein pras40: Proline-rich Akt substrate of 40kD rictor: Rapamycin-insensitive companion of mTOR msin1: Stress-activated protein kinase interacting protein 1 PI3K: Phosphatidylinositol-3-OH kinase AKT: RAC- serine/threonine-protein kinase TSC: Threonine-protein kinase/tuberous sclerosis complex LKB1: Liver kinase B1 AMPK: Mitogen-activated protein kinase TLR: Toll-like receptor Rheb: Ras homolog enriched in the brain PTEN: Phosphatase and tensin homolog deleted on chromosome 10 PIP2: Ephosphatidylinositol-3,4-bisphosphate PIP3: Phosphatidylinositol-3,4,5-triphosphate S6K1: S6 kinase 1 eIF4E: Eukaryotic translation initiation factor 4E eIF4B: Eukaryotic translation initiation factor 4B 4E-BP1: EIF4E binding protein 1 PDCD4: Programmed cell death protein 4 SKAR: S6K1 Aly/REF-like target ATF4: Activating transcription factor 4 MTHFD2: Methylenetetrahydrofolate dehydrogenase 2 CAD: Carbamoyl-phosphate synthetase HIF1: Hypoxia-inducible factor-1 ULK1: Unc-51-like kinase1 TFEB: Transcription factor EB SGK1: Serum and glucocorticoid inducible kinase 1 PKC: Protein kinase C- FLSs: Fibroblast-like synoviocytes Teffs: Effector T cells Tregs: Regulatory T cells MLS: Macrophage-like synoviocytes SMs: Synovial macrophages OC: Osteoclast TGF-: Factor- DC: Dendritic cell Flt3L: Flt3 ligand NAC: N-acetylcysteine NF-B: Nuclear factor B ROS: Reactive oxygen species Met: Metformin References McInnes IB, Schett G