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The results of this trial showed that at the end of the intervention despite the equivalent B 12 intakes pregnant women had 21 % lower serum B 12 concentrations compared with the non-pregnant controls but the concentrations of holotranscobalamin (biologically active fraction of B 12 ) were not significantly different between the two groups

Figure 2 presents the plasma Hcy and methionine levels of the experimental groups after 4 weeks of creatine supplementation

The same biotechnology approach Kyowa Hakko uses for its pharmaceutical-grade amino acids and nucleotides