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Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad

The study, with its rigorous clinical design, confirmed that the intervention group exhibited significant improvements compared to the placebo group in menstrual cycle regularity (p=0.023), total testosterone levels (p=0.043), waist circumference (p=0.030), and quality of life (p=0.034), with no reported adverse effects (108)

Importantly, in the hypothalamus, GLP-1 receptor activation stimulates the neuronal pathways that reduce appetite and food intake