Finally, as tumor cells and immune cells are both affected by these modulators, cell-type-specific delivery of them with nanostructured lipid carriers or modular envelope design [257, 258] might yield better therapeutic results, allowing, for example, the expected inhibitory function upon metabolism in tumor cells, without affecting immune cells-mediated antitumor immunity
Mechanistic insights: granulosa and cumulus cell impact Mechanistically, the follicular fluid (FF) in PCOS constitutes a unique inflammatoryoxidative niche in which neutrophil-derived products can exert direct cytotoxic effects on granulosa and cumulus cells
Habiba ES, Harby SA, El-Sayed NS, Omar EM, Bakr BA, Augustyniak M, et al
Keep the Conversation Educational, Not Promotional Stick to facts: what we know, what we don't, and what's not approved