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Independent replication of the key findings by groups outside the original laboratory has not been published, which is an additional concern for a compound with such dramatic claims

doi: 10.1186/s13568-018-0632-1 74

Patients with Pre-Existing Lipid Disorders Anyone with familial hypertriglyceridemia, familial combined hyperlipidemia, or a baseline fasting triglyceride level above 300 mg/dL before starting isotretinoin should have a formal lipid management plan in place before initiating the retinoid