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1) Impaired histamine breakdown: There are two ways your body breaks down and clears histamine: the DAO enzyme or the HMNT enzyme.[ref] Diamine oxidase (DAO) enzyme: breaking down and inactivating histamine in the gut Diamine oxidase is encoded by the AOC1 gene

In 2018, a 39 amino-acid peptide tirzepatide (LY3298176) was developed, which is similar in size to both GLP-1 and GIP with exenatide-derived C-terminal tail and thus has a prolonged half-life