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Brain Behav Immun Health 2:100037

GSH conjugation differs from other conjugation reactions in that the process does not require initial activation of the coenzyme or the substrate since the GSH, which is a nucleophile itself, is highly reactive towards an electrophilic substrate

Herbal supplements marketed for appetite suppression or metabolism should be avoided entirely during tirzepatide therapy

In cancer cells, GLS supports the production of glutamate, which is vital for the synthesis of GSH, a major antioxidant that scavenges ROS, triggering oxidative stress and eventually leading to apoptosis (211)