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Retrieved December 9, 2006

Toxicology in Vitro : an International Journal Published in Association with BIBRA 52:3340 Acknowledgements For excellent technical assistance, the authors thank the Fraunhofer ITEM PCLS team, as well as Ann-Kathrin Janze

Smith Active and placebo nicotine nasal spray ( Nicotrol ) was supplied by Pharmacia-UpJohn (Mikael Franzon, Ph.D

Structural Changes in Lungs Emphysema: destruction of alveolar walls enlarged air spaces decreased gas exchange Chronic bronchitis: mucus hypersecretion, chronic cough, narrowed airways Airway remodeling: fibrosis and thickening of bronchi airflow limitation 6