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Different impacts of mutant p53 on patient outcome were also observed in other cancers, including head and neck cancer, chronic lymphocytic leukaemia (CLL) and breast cancer [166, 168, 169]

To address motivational interviewing, most clinicians can use the five Rs (relevance, risk, rewards, repetition, roadblocks) to summarize the areas for smoking cessation ( 82 ) (Figure 6)

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We can see vaping reaching deeper into the base of adult smokers and reaching people who would likely have smoked for life. Vaping is vastly safer than smoking