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Probiotics have proven effective in alleviating HU by absorbing purines, restoring gut microbiota balance, and inhibiting XO activity

Many growth factors such as transforming growth factor (TGF)-,2 platelet-derived growth factor (PDGF),3 epidermal growth factor (EGF),4 and fibroblast growth factor (FGF),5 as well as interleukin (IL)-16 and tumor necrosis factor (TNF),7 have been evaluated in a wide spectrum of in vivo and in vitro experiments to observe their effects on different elements included in the healing process

On one hand, glucose detection using blood-alternative samples such as sweat, interstitial fluid, tears, saliva, and urine has been extensively investigated

These studies demonstrate that H