10.18632/aging.102115 62 FuianoG.SundS.MazzaG.RosaM.CagliotiA.GalloG.et al (2001)
Briefly, wild-type (wt, 5-GAGTGTGGATGACCCTTGGT-3) or mutant (mut, 5-CTCACACCTACTGGGAACCA-3) sequence in MBOAT1 promoter region or wt (5-GGTAAAGAGGCGCGGGGA-3) or mut (5-CCATTTCTCCGCGCCCCT-3) sequence in METTL1 promoter region was fused into luciferase pGL3-basic reporter vector (Promega, Madison, USA) to construct pmirGLO-MBOAT1-wt/-mut or pmirGLO- METTL1 -wt/-mut (sequences in Supplementary Table S6)
Este glucsido inhibe la tirosinasa, enzima clave en la sntesis de melanina, reduciendo progresivamente manchas establecidas
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