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For example, gray matter in the insula of smokers has been reported to be decreased [15, 18, 19], increased [20], or comparable to that among nonsmokers [17, 21]

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In 2010, states were appropriating only 2.4% of their state tobacco revenues for tobacco control, and reaching the CDC's Best Practices for Comprehensive Tobacco Control Programs ( Best Practices 2007 ) funding goal would have required an additional 13% of tobacco revenues, or $3.1 billion of the $24 billion collected (CDC 2012e)

However, only recently scientists discovered a biological explanation for this difference