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Cochrane Database Syst Reviews 2019(3)

Common Causes of B12 Deficiency Several factors contribute to vitamin B12 deficiency: Recognizing Deficiency Symptoms Vitamin B12 deficiency manifests through various symptoms that can significantly impact quality of life: These symptoms often develop slowly, leading many individuals to attribute them to aging or stress rather than nutritional deficiency

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893 Csp3-like proteins differ slightly in Cu I -binding stoichiometries, but all contain a common core of three tetrameric Cu-binding clusters (which collectively bind 12 Cu), with the additional coordination chemistry variable above or below this cluster (Figure 52)