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Dormant NADPH oxidase contains two subunits: glycoprotein (gp)91phox (for phagocyte oxidase) and p22phox [63]
In addition, knocking down ACTL6A increased the expression levels of prostaglandin-endoperoxide synthase 2 (PTGS2) (Supplementary Fig 3b), which is a ferroptosis marker 30,46
LA maintains the cellular antioxidant state indirectly through activating the NRF2 pathway, and the NRF2 pathway governs the expression of antioxidant genes (such as -glutamylcysteine synthetase (-GCL), NAD(P)H quinone oxidoreductase 1 (NQO-1), and superoxide dismutase (SOD)) for enhancing the cell's antioxidant capacity and anti-inflammatory response [34, 35]
Important notes Glutathione is produced in the liver using nutrients from the diet It serves multiple functions, such as being essential for detoxifying toxins, protecting the body against viral and bacterial infections, guarding the cardiovascular system against diabetes, and preventing the formation of tumors, among others
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