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If you must layer them in the same evening routine, apply the lightweight copper peptide serum first, wait 10 to 20 minutes for complete absorption and pH stabilization, and then follow with your retinol and a nourishing moisturizer

Specific application sequences Sequence 1: Peptides first, then retinol (same routine) Cleanse face Apply peptide serum to damp skin Wait 1-2 minutes for absorption Apply retinol Wait 1-2 minutes Apply moisturizer Best for: Most peptides (Matrixyl, Syn-Coll, general collagen peptides) Sequence 2: Retinol first, then peptides (less common) This is rarely recommended because retinol benefits from being closer to skin, and peptides are often in hydrating serums that work well after retinol

Rhonda Patrick: And he did this study where both young and older people were

The same genotypes were associated with higher nasal IgE and histamine response [59]