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Hsieh et al., Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation, J

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Importantly, Hinton and colleagues showed that human IgG2 variants harboring Fc fragments with amino acid substitutions that increase their binding affinity towards human FcRn at specifically pH 6.0, but not pH 7.4, had prolonged plasma half-lives in non-human primates (NHPs) [104]