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Sit or lay them down on their side, not their back, to reduce choking risks
time 0-last AUC 0 -inf : AUC from timepoint 0 to infinity AUC 0 -90 : AUC from timepoint 090 min BMI: Body Mass Index CI: Confidence interval C last : Observed plasma concentration at the last sampling timepoint C max : Maximum observed plasma concentration ECG: Electrocardiogram GCP: Good clinical practice h: Hours HIV: Human immunodeficiency virus HPHC: Harmful and potentially harmful constituent ICH: International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use LLOQ: Lower limit of quantification LS: Least squares (mean) Max: Maximum value mg: Milligrams Min: Minimum value mmHg: Millimetre mercury MOND: Modern oral nicotine delivery NCA: Non-compartmental analysis NGP: Next generation (nicotine) product OND: Oral nicotine delivery PES: Product evaluation scale PK: Pharmacokinetic TFNP: Tobacco-free nicotine pouch THR: Tobacco harm reduction T max : Time to C max TSNA: Tobacco-specific nitrosamine T 1 /2(z) : Terminal elimination half-life SERA: Swedish Ethical Review Authority SAE: Serious adverse event SAS: Statistical Analysis System (software) SD: Standard deviation VAS: Visual analogue scale References Centers for Disease Control and Prevention (US)
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