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Inadequate function of methionine synthase can lead to an accumulation of homocysteine, which has been associated with increased risk of cardiovascular disease and age-related neurodegenerative disease (e.g., Alzheimers disease)

found that GLP-1RAs did not significantly reduce asthma exacerbations, whereas, SGLT-2 inhibitors (SGLT-2i) were associated with a reduced risk of asthma compared to both GLP-1RAs and DPP-4 inhibitors (DPP-4i) [101]

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Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1/Kyn/AHR axis