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Referral thresholds are broadly guided by NICE but may vary according to local NHS Integrated Care System (ICS) policies

In a study by Parsad and Kanwar, disease progression was halted in 29 of 32 patients treated with minocycline 100 mg/day as monotherapy

However, according to clinical pharmacy specialist Joe B., the amount of thiamine found in a standard banana bag is woefully inadequate to reliably treat or prevent Wernickes Encephalopathy. This limitation is why many clinicians now advocate for higher-dose thiamine protocols administered separately alongside the standard banana bag formula

Researchers noted that there were less fine lines, wrinkles, and hyperpigmentation as well