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Green tea catechins like epigallocatechin-3-gallate (EGCG) and grape seed proanthocyanidins (GSPs) exhibit photoprotective properties by absorbing UVA and UVB radiation, reducing DNA damage, and inhibiting UVB-induced cyclooxygenase-2 (COX-2) expression, which is critical in the development of skin tumors 139

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Other convergent mechanisms offering therapeutic avenues for the sporadic majority include sustained neuroinflammation, persistent oxidative stress, and mitochondrial dysfunction (14)