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Dihexa induces spinogenesis in cultured hippocampal neurons Actin-enriched spines increased in number in response to both dihexa (Figure 38B&D) and Nle'-AnglV (Figure 38C&D) following 5 days of treatment at 10 "12 M concentration that started on the 7 th day in vitro (DIV7) the results revealed a near 3-fold increase in the number of spines stimulated by dihexa and greater than 2-fold increase for Nle f -AngIV

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Diagonal, scaled-identity, autoregressive (standard, heterogeneous, and moving average variations), and compound symmetry repeated measures covariance structures were all tested, and the model with the lowest Akaikes Information Criteria was considered to be the best fit

Salehi et al., 2023)