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The red blood cells become unusually large and less effective, which means now less oxygen reaches the tissues

According to a clinical trial published in the New England Journal of Medicine , Tesamorelin significantly reduced VAT and improved lipid profiles in patients with HIV-associated lipodystrophy (Falutz et al., 2010)

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Unlike setmelanotide, which can activate melanocortin receptors MC3R and MC1R in addition to MC4R 36 , RM-718 by design, avoids stimulating MC1R 40 and thereby avoids the common hyperpigmentation adverse event 41 that can arise when MC1R is stimulated 42