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In a study of 16 patients with chronic CIPN who were in remission and no longer receiving chemotherapy, 30-minute application of an 8% capsaicin patch to the feet resulted in lower patient-reported levels of pain, touch-evoked pain, and cold-evoked pain, with overall significant pain relief (Anand 2019)

This discovery of the role of FSP1 in reducing vitamin K also unraveled a longstanding mysteryidentifying the warfarin-resistant vitamin K reductase to combat anticoagulant warfarin poisoning (Fig

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