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Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging

Examination of mouse and human breast tumours revealed that tGSH levels were enriched in the TIF compared to serum (Fig

The resulting increase in Treg abundance dampens metaflammation and reduces circulating and islet levels of TNF-, IL-1, and IFN-, which in turn alleviates -cell ER stress and protects against cytokine-induced apoptosis ( Proteobacteria