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Mechanism for Extraesophageal Symptoms The mechanism for extraesophageal manifestations of GERD, such as wheeze or cough, may not always be direct aspiration or damage of mucosa in the respiratory tract but a vagally mediated reflex triggered by acidification of the distal esophageal mucosa

Research and clinical practice have established that fasted-state administration maximizes fat-mobilizing effects by optimizing the peptides metabolic signaling

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