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Alongside their in vitro study, the Thomas Jefferson University-based research group also conducted a randomized trial in which patients were treated with either NAC for three months or received no treatment

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(Oxf) 52 , 735739 (2000)

This accumulation is accompanied by downregulation of glutathione peroxidase 4 (GPX4), upregulation of acyl-CoA synthetase long-chain family member 4 (ACSL4), and elevated lipid peroxidationhallmarks of ferroptotic cell death (Taylor et al., 2008)