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Cardiovascular safety, cancer and Jak-inhibitors: differences to be highlighted

A: GHK-Cu shows 3.2-fold higher copper binding affinity than AHK-Cu and 2.8-fold better stability than DAHK-Cu

After three washes with free-serum media, cells were collected, counted, and analyzed for their fluorescence intensity using a fluorescence microplate reader (Thermo Fisher Scientific, Waltham, MA, USA) with its excitation and emission wavelengths at 488 nm and 525 nm [29, 30]

Transglutaminase 2 (Tgm2) covalently cross-links IB, further promoting NF-B nuclear translocation and enhancing the expression of phosphorylated p53 and p21