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A sufficient supply of B vitamins, including B12, is truly important for converting the food we eat into usable energy

Blood levels peak around age 20 at approximately 200 ng/mL and decline to roughly 80 ng/mL by age 60, correlating with diminished skin elasticity and regenerative capacity

There are no reported risks associated with large doses of B12, since the vitamin is water soluble and excess amounts are flushed out of the system

Cell Cycle 12:21632164 Jopling HM, Odell AF, Pellet-Many C, Latham AM, Frankel P, Sivaprasadarao A, Walker JH, Zachary IC, Ponnambalam S (2014) Endosome-to-plasma membrane recycling of VEGFR2 receptor tyrosine kinase regulates endothelial function and blood vessel formation