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Like in the general population, in cEDS fatigue is multifactorial with contributing factors including articular pain, headache, sleep disturbance, and abnormally low blood pressure often associated with postural orthostatic tachycardia syndrome (POTS) or neurally mediated hypotension (NMH), nutritional deficiency, medications, and/or allergies (present in 32% of our patients) [80, 81, 87, 90,91,92,93,94,95]

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