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Cells, particularly neurons, have developed sophisticated systems to regulate iron homeostasis through absorption, storage, and output, involving transferrin (TF)-transferrin receptor (TfR), ferritin (FT), and ferroportin (FPN) (Figure 1B

doi:10.1038/s41585-023-00768-5 Di, Xingpeng et al

In research, it functions as a melanocortin receptor agonist derived from the C-terminal region of -MSH

For instance, Ferrostatin-1, a specific ferroptosis inhibitor, has demonstrated significant attenuation of adriamycin-induced cardiac injury and heart failure in murine models, suggesting a promising drug target for CAD treatment