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When PK is highly active, the rate of mitochondrial ATP production via oxidative phosphorylation is reduced as a result of reduced ADP transport into the mitochondria

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Reactive oxygen species ROS, which are the molecules containing highly unstable oxygen radicals, such as superoxide (O 2 ) and hydroxyl group (OH), usually can be rapidly transformed to more stable non-radicals like hydrogen peroxide (H 2 O 2 ) and hypochlorous acid, which can diffuse easily [4] [5]

But the negative reviews emphasize dependence concerns and difficulty transitioning off the medication