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82 MTX has been proposed to participate in the process of folate antagonism, adenosine signaling, the blocking of methyl-donor production involved in reactive oxygen species, downregulation of the adhesion-molecule expression, modification of cytokine profiles, and the downregulation of eicosanoids and MMPs

doi: 10.1590/s1807-59322008000600019 52 ShahinAAIsmailMMSalehAMMoustafaHAAboul-EllaAAGabrHM

Community reports suggest possible benefits, but essentially zero quality human trials exist

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