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For endometriosis patients who have already experienced bone density reduction from GnRH agonist therapy, adding another potential contributor to bone loss requires careful monitoring

However, these compounds are associated with Nrf-2-independent adverse effects, which prevented their clinical use despite their beneficial induction of glutathione synthesis

Data limitations: No completed human efficacy trial exists for any indication, and the literatures short observation windows mean long-term safety in either animals or humans remains unestablished

Factors such as age and associated medical conditions can also impact individual response to TB-500