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Since the list of contraindications of Vit B12 is really restrained to Leber optic neuropathy as it may aggravate it and to advanced renal failure since the injections may include aluminum in its components, we may suggest to consider systematically supplementing PD patients with B12 in the absence of contraindications or potential adverse effects (McCarter et al

Chronic treatment should be with an oral B12 preparation

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