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TRO40303, a novel MPTP inhibitor, interacts with mitochondrial extraporters, delaying MPTP opening independently of CypD, and reducing membrane potential loss and necrosis in pancreatic acinar cells, ultimately providing systemic protection in AP ( Furthermore, CypD inhibitors have shown promise in mitigating necrosis in both mouse and human acinar cells, improving the severity of AP by safeguarding mitochondrial integrity (202)

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