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Immunity 40 , 608620 (2014)

Bacteria synergized with PD-1 blockade enhance positive feedback loop of cancer cells-M1 macrophages-T cells in glioma

A review of 38 RCTs comprising 7,551 patients on ICI therapy evaluated the incidence of endocrine irAEs and found a higher incidence of hypo and hyperthyroidism, especially in patients receiving combined ICI therapy (OR: 3.81