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Untangling the potential effects of these diuretics on fuel homeostasis is additionally complicated by the intricate relationships among all components of the MetS, glucose intolerance (often confused with prediabetes), T2D, hypertension, the specific diuretic treatment and the functional redundancy that may exist among diuretic-sensitive targets

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It's that they address only surface-level symptoms while ignoring the deeper mechanisms that actually create and maintain wrinkles