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The anti-melanoma effect of natural drugs is also mediated through a number of other mechanisms, including stimulation of activity of caspase, angiogenesis inhibition, and tumor-promoting proteins inhibition including Pl3-K, B-cell lymphoma 2 (Bcl-2), signal transducer and activator of transcription 3 (STAT3) and Matrix metalloproteinases (MMPs) [39]

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IGF-1 LR3 subsequently emerged as a recognised compound within peptide research and continues to be referenced throughout scientific literature examining growth factor signalling systems