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Serum analysis of 32 patients with high-frequency migraine revealed abnormally low levels of alpha-lipoic acid (ALA) and lactate, along with abnormally high levels of peroxides in 46.9% of the patients, further supporting the role of oxidative stress and metabolic alterations in the pathophysiology of migraine (40)

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N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects (SAMSON)