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Pro-inflammatory factors such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) are regarded as depression biomarkers (Carniel and da Rocha, 2021)

The novelty of this review lies in its integrative approach, moving beyond a mere description of disparate pathways to synthesize a coherent framework that connects key metabolic nodessuch as the mammalian target of rapamycin (mTOR)-hypoxia-inducible factor 1-alpha (HIF-1)-glycolysis axis, AMP-activated protein kinase (AMPK)-FAO signalinginto a dynamic immunometabolic network ( Figure 1 )

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