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ATG9 may also promote redistribution of the lipids to the inner layer through lipid scramblases ( After the phagophore has reached its final size, VMP1 promotes the dissociation of contacts between the ER and the phagophore via local changes in Ca 2+ concentrations until the final scission event is then mediated by the endosomal sorting complexes required for transport (ESCRT) machinery ( Figure 1 , panel 3)

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