stated that hepatoceullar carcinoma(HCC)-derived lysophosphatic acid(LPA) plays a critical role in promoting differentiation from PTFS into a CAF-like myofibrobast phenotype (131)
Cancer Res 66 : 1129811304 Gore SD, Baylin S, Sugar E, Carraway H, Miller CB, Carducci M, Grever M, Galm O, Dauses T, Karp JE, Rudek MA, Zhao M, Smith BD, Manning J, Jiemjit A, Dover G, Mays A, Zwiebel J, Murgo A, Weng LJ, Herman JG (2006) Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
296 Therefore, PARPs have antiviral activity against multiple classes of viruses, including retroviruses, alphaviruses, filoviruses, herpesviruses, adenoviruses and coronavirus through enhancing the innate immunity
For instance, stearoyl-CoA desaturase 1 (SCD1) utilizes the mechanical signaling pathway to orchestrate lipid metabolism reprogramming and enhance membrane fluidity, thereby facilitating invasive migration and metastasis of hepatocellular carcinoma (HCC) cells (53)