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Taken together, these studies suggest that C-terminal truncated Syn variants may act as molecular decoy sequestering heterogeneous molecules, both proteins and membrane organelles, in their vicinity through nonfunctional interaction, leading to diffuse cellular aggregates or LB nucleation, as observed in various neurodegenerative disorders 83

Tips for Taking Natural Desiccated Thyroid Medication (Armour Thyroid, Nature-throid, WP thyroid, & NP Thyroid) Natural desiccated thyroid includes a combination of T4 and T3 thyroid hormones (in addition to other thyroid hormones)

Overexpression of the -synuclein mutant A53T in transgenic animals demonstrates that A53T localizes to mitochondrial membranes as a monomer, inhibiting complex I and increasing mitochondrial autophagy [65]

Although both pre-pro-HGF and the active disulfide-linked heterodimer bind Met with high affinity, it is only the heterodimer that is capable of activating Met (Lokker et al., 1992